Jiachen Chen

PhD in Biostatistics from BUSPH.

Statistical Methodology

  1. Chen, J., Murabito, J.M., Lunetta, K.L. (2026+)
    MGRFusionNet: A Graph-Recurrent Framework for Integrating Molecular Omics and Longitudinal Phenomics in Health Outcome Prediction.
    Bioinformatics
    Under Review

  2. Chen, J., Huang, D., Wang L., Lunetta, K.L., Murabito, J.M., Peloso G., Mukherjee D., Cheng H. (2026+)
    Transfer Learning Under High-Dimensional Graph Convolutional Regression Model for Node Classification.
    IEEE Transactions on Network Science and Engineering
    Under Review arXiv

  3. Wang L.†, Chen, J.†, Lunetta, K.L., Huang, D., Cheng H., Mukherjee D. (2026+)
    Transfer Learning Under High-Dimensional Network Convolutional Regression Model.
    Biometrics
    Under Review arXiv

  4. Chen, J., Murabito, J.M., Lunetta, K.L. (2025)
    ONDSA: a testing framework based on Gaussian graphical models for differential and similarity analysis of multiple omics networks.
    Briefings in Bioinformatics, 26(1), bbae610
    DOI
    2023–2024 BUSPH Biostatistics Student Paper Award

  5. Chen, J.†, Bie, R.†, Qin, Y., Li, Y., and Ma, S. (2022)
    Lq‐based robust analytics on ultrahigh and high dimensional data.
    Statistics in Medicine, 41(26), 5220–5241
    DOI

  6. Chen, J., Zhou, X., Li, F., & Spiegelman, D. (2022)
    swdpwr: A SAS macro and an R package for power calculations in stepped wedge cluster randomized trials.
    Computer Methods and Programs in Biomedicine, 213, 106522
    DOI

Applications in Cognitive Aging and Genetic Epidemiology

  1. Chen, J., Murabito, J.M., Peloso G., Iyer, S., Doyle, M.F., Lunetta, K.L. (2026+)
    A Proteomic Signature of Frailty Pace Captures Functional Aging and Predicts Age-Related Diseases and Mortality.
    Nature Aging
    Under Review

  2. Adly, A., Bernatz, S., Bontempi, D., …, Chen, J.,…, Aerts, J.H. (2026+)
    Deep Learning-based Lung Health Score from Computed Tomography in Adults.
    npj Digital Medicine
    Under Review

  3. Bernatz, S., Prudente, V., Pai, S.,…, Chen, J.,…, Aerts, J.H. (2026)
    Thymic Health Consequences in Adults.
    Nature
    DOI

  4. Chen, J., Doyle, M.F., Iyer, S., Cao Y., Ragab, A.A., Murabito, J.M., Lunetta, K.L. (2026)
    Circulating immune cell phenotypes are associated with inflammatory biomarkers in dementia-free participants: Framingham Heart Study Offspring cohort.
    Scientific Reports
    DOI

  5. Iyer, S., Cao Y., Liebegott R., Chen, J., Ragab, A.A., Doyle, M.F., Lunetta, K.L., Murabito, J.M. (2025)
    Association of Circulating Immune Cell Phenotypes and Peripheral Inflammatory Biomarkers with Depressive Symptoms in the Framingham Heart Study.
    Psychoneuroendocrinology
    DOI

  6. Rotti, L., Murabito, J.M., Chen, J., Cao Y., Ragab, A.A., Liu, C., Wang, M., Doyle, M.F., Lunetta, K.L. (2025)
    Immune Cells and Inflammatory Proteins are Associated with Future DNA Methylation Biological Aging Measures in the Framingham Heart Study Offspring Cohort.
    Geroscience
    DOI

  7. Ragab, A.A., Doyle, M.F., Chen, J., Lunetta, K.L., Murabito, J.M. (2025)
    Alcohol consumption and immune cell profiles: Insights from the Framingham Heart Study.
    Alcohol: Clinical and Experimental Research
    DOI

  8. Fang, Y., Chen, J., Mez, J., Satizabal, C.L., Alosco, M.L., Qiu, W.Q., Doyle, M.F., Murabito, J.M., Lunetta, K.L. (2025)
    Modeling heterogeneity in cognitive trajectories in the Framingham Heart Study.
    Frontiers in Aging Neuroscience
    DOI

  9. Cao Y., Salvati L.R., Chen, J., Ragab, A.A., Mez, J., Satizabal, C.L., Alosco, M.L., Fang, Y., Qiu, W.Q., Lunetta, K.L., Murabito, J.M., Doyle, M.F. (2025)
    The Association of Circulating Immune Cells with Cognitive Function, Brain Imaging, and Incident all-cause and Alzheimer’s Dementia: The Framingham Offspring Study.
    Journal of Gerontology: Biological Sciences, glaf067
    DOI

  10. Chen, J.†, Ragab, A.A.†, Doyle, M.F., Alosco, M.L., Fang, Y., Mez, J., Satizabal, C.L., Qiu, W.Q., Murabito, J.M., Lunetta, K.L. (2024)
    Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.
    Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 1-14
    DOI

  11. Kang, M., Li, C., Mahajan, A., Spat-Lemus, J., Durape, S., Chen, J., et al. (2024)
    Subjective Cognitive Decline-Plus: Longitudinal assessment and risk for cognitive impairment.
    JAMA Psychiatry
    DOI
    2024 Publication of the Year Award by the Alzheimer’s Association ISTAART and the SCD PIA

  12. Ragab, A. A., Doyle, M. F., Chen, J., Fang, Y., Lunetta, K. L., Murabito, J. M. (2024)
    Immune cell phenotypes and mortality in the Framingham Heart Study.
    Immunity & Ageing, 21(1), 37
    DOI
    Editor’s Pick

  13. Chen, J., Doyle, M.F., Fang, Y., Mez, J., Crane, P.K., Scollard, P., Satizabal, C.L., Alosco, M.L., Qiu, W.Q., Murabito, J.M., Lunetta, K.L. (2023)
    Peripheral inflammatory biomarkers are associated with cognitive function and dementia: Framingham Heart Study Offspring cohort.
    Aging Cell, 22(10), e13955
    DOI

  14. Fang, Y., Doyle, M.F., Chen, J., Mez, J., Satizabal, C.L., Alosco, M.L., Qiu, W.Q., Lunetta, K.L. and Murabito, J.M. (2023)
    Circulating immune cell phenotypes are associated with age, sex, CMV, and smoking status in the Framingham Heart Study offspring participants.
    Aging (Albany NY), 15(10), 3939
    DOI

  15. Fang, Y., Doyle, M.F., Chen J., Alosco, M.L., Mez, J., Satizabal, C.L., Qiu, W., Murabito, J.M., Lunetta, K.L. (2022)
    Association between inflammatory biomarkers and cognitive aging.
    PLOS One, 17(9), e0274350
    DOI

† indicates joint first authorship.