Jiachen Chen

PhD candidate in Biostatistics at BUSPH.

Frailty and Cognitive Aging: Shared Mechanisms

This research investigates the interconnected biological mechanisms driving both physical frailty and cognitive decline, including chronic inflammation, immune dysfunction, and metabolic dysregulation. Using AI/ML tools and multi-omics integration, we aim to identify mechanisms and pathways that explain the shared underpinnings between frailty phenotypes and neurodegenerative processes.

Inflammation, Immunosenescence, and Cognitive Aging

This research series investigates how peripheral inflammation and immunosenescence contribute to cognitive impairment and dementia, using data from the Framingham Heart Study. Through a combination of inflammatory protein profiling, immune cell phenotyping, and brain imaging, these studies have advanced our understanding of systemic aging and brain health.
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ONDSA: A Testing Framework for Omics Network Structures Comparison

A novel statistical testing framework for identifying differential and similar omics network structures across multiple groups based on sparse Gaussian Graphical Models.
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swdpwr: Power Calculation for Stepped Wedge Cluster Randomized Trials

An R package and SAS macro for power/sample size calculation of stepped wedge cluster randomized trials (SWCRT).
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More projects are under construction and will be available shortly.